BreastScreen Norway

BreastScreen Norway Poster

BreastScreen Norway (Mammografiprogrammet) is a population-based, nation-wide screening program for breast cancer. The program offers biennial mammographic screening to all women aged 50-69, based on their personal identification number. The program aims to detect breast cancer at an early stage, reducing mortality from the disease and enabling less invasive treatments. As part of the EuCanScreen Joint Action, Norway’s approach might serve as a model for high-quality, evidence-based screening.

 

Screening participation and outcomes

Participation rate in each screening round have been stable at about 75% since start-up of the program in 1996, while 84% of the invited women have attended at least once over a ten-year period. The program has demonstrated a reduction in breast cancer mortality, with estimates of 20-30% decrease in breast cancer deaths among women invited (intention to treat) and about 40% reduction among those who have attended the program once or more (per protocol). Early detection and improved treatment are considered the main reasons for the reduced mortality.

How BreastScreen Norway works:

  • – Invitation by mail: Women in the target group receive an invitation letter from the Cancer Registry of Norway, either by post or digitally, to participate in screening. The invitation includes a leaflet outlining the benefits and drawbacks of participation.
  • – Appointment scheduling: The Cancer Registry send invitation letters with prescheduled time and place for examination.
  • – Mammographic examination: A two-view digital mammogram is performed at designated screening units (26 stationary and 4 mobile units). The screening mammograms are independently read by two breast radiologists.
  • – Follow-up for abnormal findings: If suspicious findings are detected, women are recalled for further assessment at one of the 16 breast centres in the country. Further assessment includes additional imaging and a needle biopsy if needed.
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Program structure

BreastScreen Norway involves multiple stakeholders who collaborate to ensure effective planning, performance, and quality assurance.

 

Key stakeholders

  • – Cancer Registry of Norway: Responsible for screening invitations and negative result letters, information dissemination, managing IT systems and infrastructure, and coordinating technical quality assurance. Additional tasks include registration in a national database, monitoring, quality control and improvement, research on breast cancer and mammography screening, and collaboration with national and international experts.
  • – Women in the target group: The primary focus of the program.
  • – Breast centres: Responsible for screening, image interpretation, further assessment, treatment, and follow-up. Tasks include managing inquiries, coordinating invitations, performing screening examinations at dedicated units (stationary or mobile), independent double reading, organizing multidisciplinary meetings, and maintaining professional competence (affiliated to the RHAs, see next bullet point).
  • – Regional Health Authorities (RHAs): Norway is divided into four RHAs, each responsible for organizing and delivering breast screening services within their region. Their responsibilities include ensuring service provision through affiliated breast centers, overseeing technical quality assurance and equipment maintenance, and managing the economic framework, including patient co-payments.
  • – Mobile screening units: Operated by Vestre Viken Health Trust, these units ensure access to mammography screening in parts of Norway´s rural and remote areas.
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Governance structure

  1. – Advisory group for BreastScreen Norway: Provides clinical and technical expertise to maintain program standards and improve diagnostic practices.
  2. – National steering group for cancer screening programs: Established in 2022 to provide strategic direction and oversee the effectiveness and safety of the cancer screening programs.
  3. – Ministry of Health and Care Services: Holds overall responsibility for national health policy and approves major changes to the program.
  4. – Norwegian Directorate of Health: Provides regulatory oversight and advises on program operations and appoints and supports the national steering group for cancer screening programs.
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Research in breast cancer screening

BreastScreen Norway aims to be in the forefront of quality improvement and research in breast cancer screening, with a strong emphasis on improving accuracy and efficiency through advanced technologies and personalised screening approaches.

Read about our research here: https://www.kreftregisteret.no/en/screening/BreastScreen_Norway/research-in-breastscreen-norway/

 

AI in mammographic screening

In November 2024 BreastScreen Norway launched a randomised controlled trial on AI in mammographic screening. The study will include 140,000 women aged 50-69, the target group for the screening program. Led by Solveig Hofvind, head of BreastScreen Norway, the study aims to determine whether AI can match or surpass radiologists in detecting breast cancer.

Initially implemented in Western Norway (Helse Vest), the study will later expand nationwide. Hofvind highlights that the results could pave the way for expanding screening age groups and tailoring screening frequency based on individual risk.

“With increasing breast cancer incidence in both younger and older women, and limited radiologist resources, we need solutions to ensure a modern and effective screening program,” says Hofvind.

Previous studies have shown AI can detect the same breast cancer tumours as radiologists, even identifying small tumours at an early stage. However, these studies were based on retrospective data. This new trial is the first in Norway to test AI as an integrated tool for radiologists in real-time screening.

Women participating in the study will be randomly assigned to have their ammograms interpreted either by AI in combination with one or two radiologists or by the standard method of two radiologists independently reviewing the images. The screening process itself remains unchanged; only the image interpretation differs.

Figure BreastScreen

Personalised screening approaches

BreastScreen Norway is also exploring risk-stratified screening, moving away from a one-size-fits-all approach.

A major study evaluated AI’s ability to predict breast cancer risk years before diagnosis. Researchers applied an AI algorithm to mammographic images from nearly 120,000 women screened between 2004 and 2018. The findings revealed that the AI-generated risk score was significantly higher for women who later developed breast cancer, with the affected breast showing nearly twice the AI score of the opposite breast, even four to six years before a clinical diagnosis. These results suggest AI could play a vital role in risk stratification, allowing for more personalised screening strategies, offering high-risk women more frequent monitoring while reducing unnecessary screening for low-risk individuals. DOI: 10.1001/jamanetworkopen.2024.37402

 

Digitalisation and data integration

Norway benefits from a comprehensive cancer registry and digital health infrastructure, allowing seamless integration of screening data with patient records. This enables large-scale epidemiological research and quality monitoring.

 

Collaboration and future directions

Norway actively collaborates with European partners to share best practices and research insights. Future directions for BreastScreen Norway include:

  • – Expanding AI validation studies
  • – Further refining personalised screening models
  • – Enhancing cross-border research collaboration on breast cancer screening

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Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Health and Digital Executive Agency (HADEA). Neither the European Union nor HADEA can be held responsible for them.

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The general objective of EUCanScreen is to assure sustainable implementation of high-quality screening for breast, cervical and colorectal cancers, as well as implementation of the recently recommended screening programs – for lung, prostate and gastric cancers. EUCanScreen will facilitate the reduction of cancer burden and achieving equity across the EU.

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This project has received funding from the European Union’s EU4HEALTH Programme under the Grant Agreement no 101162959

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